January 11 2010 To continue our report from 181

first_imgJanuary 11, 2010 To continue our report from 1/8/10, the group of art students from the Kansas City Art Institute met with Paolo Soleri for the weekly SCHOOL OF THOUGHT philosophy session. [photo & text: sue] The theme for discussion last week was THE LEAN LINEAR CITY [see a series of postings about the Lean Linear City from Nov. 27. to Dec. 14. 2009]. School of Thought occurs almost every Wednesday at 3 pm and is open to the public and visiting groups. If you plan to attend, please call our visitors center at 928 632-6217 for confirmation. [photo & text: sue] The Kansas City Art Institute group. This photo speaks for itself. [photo: & text: sue]last_img

Czech DTH operator Skylink has added Sonys males

first_imgCzech DTH operator Skylink has added Sony’s male-skewed channel AXN to its line-up.The channel, which airs programmes including CSI: New York and NCIS, is available in Skylink’s Mini, Multi, Kombi, Multi HD, Komplet and Flexi 7 packages.The operator has also added music channel Retro Music Television to its Digital package. The channel broadcasts music from the 1960s to the 1990s.last_img

TGen City of Hope to develop cell therapy manufacturing facility in Phoenix

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 2 2018City of Hope, a world-renowned independent cancer research and treatment center, and its affiliate, Translational Genomics Research Institute (TGen), have announced a letter of intent to develop a state-of-the-art cell therapy manufacturing facility in the Phoenix Metropolitan Area, a move that would improve the speed at which stem cell research and cancer treatment is delivered.The Phoenix facility would model City of Hope’s three Current Good Manufacturing Practice (cGMP) facilities in Duarte, California, which have produced well over 1,300 cell and gene therapy products and oncology drugs for many cancer clinical trials across the nation. City of Hope is one of a small number of select cancer centers in the U.S. to provide both biological and chemical GMP manufacturing at a single institution. Its facilities have the ability to produce both gene therapy viruses and cells needed for CAR T therapies.”City of Hope is dedicated to innovation in biomedical science and has one of the most comprehensive CAR T cell programs in the world with 16 ongoing CAR T clinical trials,” said Robert W. Stone, president and chief executive officer of City of Hope as well as vice chairman of the TGen board of directors. “Cancer patients need effective treatments now. City of Hope and TGen are working to quickly move effective therapies from the laboratory to patients’ bedside. Additional cGMP facilities will help us expand our capabilities to serve people in Arizona and across the nation.”Demand for clinical cell therapies is expected to grow 42 percent annually over the next decade, according to “Cell Therapy Manufacturing Market.” Most cell therapy manufacturing facilities are at capacity or over capacity because demand is outpacing production rates.”This significant investment further enhances Arizona’s reputation as a hub for bioscience and health care innovation,” said Arizona Governor Doug Ducey. “Our state offers a strong concentration of talent ready to meet the needs of this facility. The work being conducted by City of Hope and TGen is critical in the fight against cancer, and Arizona is proud to play a role in it.”Related StoriesExciting study shows how centrioles center the process of cell divisionNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’The planned facility would meet an urgent need of accelerating cures for patients in Arizona, Southern California and elsewhere. The facility would also provide additional opportunities to partner and collaborate with scientists in Arizona, an important objective for TGen, an affiliate of City of Hope.At this future facility, chimeric antigen receptor (CAR) T cells, which have demonstrated durable cancer remission in blood cancers such as leukemia and lymphoma, would be among the cells that are produced. The new facility could also support the cell therapy production needs of pharmaceutical and biotechnology companies who need this kind of specialized GMP capability to move clinical trial programs forward.”The road to future cancer cures requires genomic-enabled medicine and the type of immune-system enhancements that would result from this cell therapy manufacturing facility, which will provide local access to new treatments for Arizona patients,” said Jeffrey Trent, Ph.D., TGen president and research director. “City of Hope’s clinical and manufacturing expertise in immunotherapy is at the forefront of this field, and combined with TGen’s genomic testing, offers patients new hope for their future.”The Arizona Commerce Authority will work in partnership with City of Hope and TGen to provide workforce development assistance through its Navigator and local One-Stop programs.Source: https://www.cityofhope.org/news/city-of-hope-and-tgen-announce-cell-therapy-facilitylast_img read more

Gujarat Alpesh Thakor another former Congress MLA set to join BJP

first_imgGujarat: Alpesh Thakor, another former Congress MLA set to join BJPFormer Congress MLAs Alpesh Thakor and Dhavlsinh Zala are set to join the ruling BJP in Gujarat.advertisement Press Trust of India AhmedabadJuly 16, 2019UPDATED: July 16, 2019 00:13 IST Alpesh ThakorFormer Congress MLAs Alpesh Thakor and Dhavlsinh Zala are set to join the ruling BJP in Gujarat.Dhavlsinh Zala indicated this after a meeting of the Thakor Sena, an outfit founded by Alpesh Thakor, Monday in Ahmedabad.Both of them had apparently cross-voted in the Rajya Sabha polls in Gujarat held on July 5 and then resigned as Congress MLAs.”A meeting of the core committee of our Thakor Sena was held today in which they gave permission to Alpesh Thakor and me to join the BJP,” Zala told reporters after the meet. Alpesh Thakor was not present at the meeting,” he said.”Now, Alpesh Thakor has been authorised to negotiate with BJP leaders and fix a date for our joining that party,” Zala further said.Alpesh Thakor (43) had emerged as a prominent OBC leader after the Patel quota agitation of Gujarat in 2015. He had formed the Thakor Sena, an outfit of his OBC Thakor caste.Before the December 2017 state elections, he had joined the Congress and later got elected from the Radhanpur assembly constituency in Patan district.However, he soon fell out with the Congress leadership and had resigned from all organisational posts before the 2019 Lok Sabha elections, but stayed in the opposition party.Alpesh Thakor and Zala had apparently voted for BJP candidates S Jaishankar (foreign minister) and Jugalji Thakor in the Rajya Sabha polls instead of Congress nominees. Both of them had quit as Congress MLAs just after voting.Both the BJP candidates had emerged victorious.Zala was elected from Bayad in Sabarkantha district in the 2017 assembly polls.Speculation was rife in Gujarat that Alpesh Thakor will join the BJP before the April-May 2019 Lok Sabha polls. However, that did not happen.ALSO READ | Ahmedabad amusement ride collapse: Six booked for culpable homicideALSO WATCH | BJP fields External Affairs Minister Jaishankar for Gujarat Rajya Sabha seatFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnupriya Thakur Tags :Follow Alpesh ThakorFollow Gujarat Nextlast_img read more

Osteoporosis Risks Symptoms and Treatment

first_img Ethnicity: White and Asian women have the highest risk of osteoporosis, while African American and Hispanic women have a lower risk. Weight-bearing exercise can help keep bones strong and prevent or slow osteoporosis progression. Credit: Shutterstock Nutrition: Eating a diet that’s low in calcium and vitamin D increases osteoporosis risk. This article is for informational purposes only and is not meant to offer medical advice. Being a couch potato: Not getting enough physical activity or too much bed rest following an injury, illness or surgery weakens bones over time. Osteoporosis risk factors The following factors can increase a person’s risk of developing osteoporosis, according to the Cleveland Clinic. Age: Bones typically become thinner and weaker with age. Osteoporosis treatment and medications People with advanced osteopenia as well as those with osteoporosis need medication to reduce their risk of fractures. Bisphosphonates are usually the first drugs used to treat osteoporosis, but while they help slow bone loss, they don’t help build new bone. These drugs include alendronate (Fosamax), risedronate (Actonel) and ibandronate (Boniva). Studies have shown that alendronate can reduce the risk of spine and hip fractures by up to 50%, Rosen said. Once a person has started treatment for osteoporosis, bone-density testing should be repeated every two to three years to monitor how the density is changing and whether treatment is working, Rosen said. For severe osteoporosis, patients may need one of three medications given by injection that actually build new bone, Rosen said. These include teriparatide (Forteo), abaloparatide (Tymlos) and romosozumab (Evenity). But after a year on these bone-building drugs, a patient needs to take bisphosphonates; otherwise, all the bone-density gains will be lost, Rosen said. In addition to medication, people with osteoporosis should aim to include 1,200 milligrams of calcium a day in their diet, from food or supplements (preferably calcium citrate), Rosen said. He also recommends taking 1,500 to 2,000 International Units (IU) of supplemental vitamin D each day. Being physically active is also beneficial for people with osteoporosis. Rosen recommends regular workouts that include weight-bearing aerobic activity, as well as strength training, balance and posture exercises. Additional resources: Consuming adequate amounts of foods rich in calcium and vitamin D throughout life. Osteoporosis is a common disease that makes bones weak, thin, brittle and more likely to break. The condition typically occurs in women after menopause and can increase the risk of fractures, especially in the hip, spine and wrist, according to the National Institutes of Health. The condition is often called a “silent disease” because bone loss can happen slowly and without any warning signs. People may not be aware they have osteoporosis until they break a bone, lose height or develop hunched posture. About 10 million Americans have osteoporosis, and another 44 million have low bone mass, or osteopenia, placing them at increased risk for osteoporosis, according to the National Osteoporosis Foundation. There are a number of factors that may lead to osteoporosis, said Dr. Harold Rosen, an endocrinologist and director of the Osteoporosis Prevention and Treatment Center at Beth Israel Deaconess Medical Center in Boston. One such factor is the accelerated bone loss that occurs after menopause, he said. Men also lose bone as they age, normally once they’re in their 60s and 70s, Rosen said. Some men think osteoporosis affects only women, but it strikes men too, he explained. Low calcium intake and low vitamin D levels in the body can also lead to bone loss, Rosen told Live Science. The body needs a good supply of calcium and other minerals to form bone, and vitamin D helps absorb calcium from food and incorporate the nutrient into bone. In addition, unhealthy habits, such as smoking and excessive drinking, can speed up bone loss, he said. Bone Density Decreases in SpaceBone loss is a serious issue that has plagued astronauts since the dawn of the Space age. In the microgravity environment bones are remodeled with a decrease in mineral density. Good nutrition, increased vitamin D intake and exercise are used to battle the issue aboard the ISS.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65900-osteoporosis.html?jwsource=cl已复制直播00:0002:4102:41Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball02:31Surgical Robotics00:29Video – Giggly Robot关闭  Family history: People whose parents had a hip fracture may be more likely to develop the disease. Osteoporosis symptoms and diagnosis Osteoporosis may cause no symptoms in its early stages, and as a result, the disease can go unnoticed for decades. Some visible signs of osteoporosis may be a loss of height and a curve in the upper back, which may cause stooped posture. A “dowager’s hump” may occur when several vertebrae collapse from osteoporotic fractures in the spine. Other symptoms may include back pain, from a fracture or a collapsed vertebra in the spine, or tooth loss, if osteoporosis has affected the jawbone. Hip fracture is another serious consequence of osteoporosis. About 20% of older adults who fracture a hip die within one year from complications of the broken bone or the surgery needed to repair it, according to the National Osteoporosis Foundation. Doctors may perform a bone mineral density (BMD) test to determine if a patient has osteoporosis, according to the Mayo Clinic. The test uses a special X-ray machine to measure the mineral content at three different bone sites, typically the hip, the spine and the top of the femur. The scan can reveal if a person has low bone mass at any of these three bone sites by comparing the patient’s bone density to the normal bone density in a healthy 30-year-old person of the same sex. BMD testing is recommended for women who are 65 or older and for women 50 to 64 who have certain risk factors for the disease. Men over the age of 70 or younger men with risk factors should also be screened for osteoporosis. Review this list of calcium-rich foods from the University of California, San Francisco Medical Center.center_img Medical problems: Numerous health conditions and diseases can also increase a person’s risk for osteoporosis. Maintaining a healthy lifestyle, such as avoiding smoking and limiting alcohol consumption, reduces bone loss. Getting regular weight-bearing exercise. How bone changes over time The body is continually breaking down small areas of old bone tissue, a process called bone resorption, and replacing that old tissue with new bone tissue. During childhood and adolescence, new bone is deposited faster than old bone is removed. This makes bones larger, heavier and denser. Peak bone mass, or when bones reach their maximum density and strength, typically occurs around age 30 for both sexes. Around age 35, bone breakdown occurs faster than the replacement by new bone, causing a gradual loss of bone mass, according to the National Institute on Aging. Women undergo more-rapid bone loss in the first few years after menopause (around age 51) than in their 30s and 40s because the ovaries produce much less estrogen, a hormone that protects against bone loss, according to The American College of Obstetricians and Gynecologists. Men in their 50s and 60s also start to lose bone mass, but at a slower rate than women do. It’s not until ages 65 to 70 that men and women begin losing bone mass at about the same rate. For that reason, osteoporosis is more common in women. The condition affects about 25% of women and 5% of men ages 65 and over, according to the Centers for Disease Control and Prevention. Can osteoporosis be prevented? The more bone a person builds early in life, the better that individual can resist bone loss later on. Prevention should start when people are younger, during their peak bone-building years, with the following steps, according to the National Osteoporosis Foundation: Body size: Petite and thin people are at greater risk of this condition because they have less bone to lose than people with larger frames and more body weight. Download a helpful brochure from Osteoporosis Canada on managing osteoporosis through exercise. Sex: Women are more likely to develop osteoporosis than men, because women have less bone tissue and lose bone faster after menopause. Learn more about osteoporosis in men from the National Institutes of Health. Unhealthy habits: Smoking and consuming too much alcohol can both increase bone loss. Osteoporosis bones are porous and weak compared to healthy bones that are more dense. Credit: Shutterstock Medications: Using certain drugs on a long-term basis can lead to bone loss. These medicines include corticosteroids, such as prednisone; heparin, a blood thinner; selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants; and aromatase inhibitors, used to treat breast cancer.last_img read more