5% EBB with Globus’ 2018 African safaris, tented camp stays Tags: Globus Monday, July 31, 2017 Posted by Travelweek Group << Previous PostNext Post >> TORONTO — The Globus family of brands is debuting new nine- to 15-day African safaris next year, including two new Cosmos tours: the nine-day On Safari in Kenya and the 14-day South Africa: From the Cape to Kruger.Clients who book and deposit any 2018 Globus Asia, Africa or South Pacific vacation by May 1, 2018 automatically save 5% on the land package. Cosmos travellers booking by Sept. 12, 2017 will save $50 per person.“Our tours are designed to combine the best of immersive experiences – from encountering chimps and elephants in safe sanctuaries to meeting Cape Town chefs in their own kitchens,” says Stéphanie Bishop, Managing Director in Canada for the Globus family of brands.All of Globus’ Africa vacations are Small Group Discovery tours with a maximum of 20 travellers per departure. In addition, every one of Globus’ Africa vacations – from the Splendors of South Africa & Victoria Falls to Kenya: A Classic Safari and Tanzania: The Serengeti & Beyond to Kenya & Tanzania: The Safari Experience – offers travellers Local Favorites (culinary and cultural insights) and luxury accommodations.More news: AMResorts has a new Sr. Dir. of Cdn. Sales & Consortia Rel’nsFor clients looking for more affordable access to Africa, for the first time Cosmos has added Africa, with two itineraries for 2018 priced from $3,69 (excluding air) to East and South Africa. Solo travellers can avoid the single supplement with Cosmos’ Guaranteed Share program.Monograms has Africa itineraries too, ranging from nine to 15 days.With any Globus family of brands vacation booking to Southern or East Africa the company makes a contribution to South Africa National Parks (SANParks) and its Honorary Ranger program to SAVE THE RHINO as well as the LION RECOVERY FUND which is part of the Wildlife Conservation Network. Share
Agents & Brokers Attorneys & Title Companies Investors Lenders & Servicers Mortgage Applications Mortgage Bankers Association Mortgage Rates Purchase Loans Refinance Service Providers 2013-11-27 Tory Barringer in Origination Mortgage Applications Experience Slight Decline Last week saw another drop in mortgage application volume, the “”Mortgage Bankers Association””:http://mba.org/default.htm (MBA) reported in its Weekly Applications Survey.[IMAGE]MBA’s Market Composite Index, a measure of mortgage loan application volume, fell a seasonally adjusted 0.3 percent the week ending November 22, the group [COLUMN_BREAK]reported. It was the fourth straight week of decreases in loan application activity.On an unadjusted basis, the index declined 9 percent week-over-week.Refinance applications increased 0.1 percent from the previous week, with refinances making up 66 percent of total application volume (up from 64 percent).That gain was offset by a slight drop in the seasonally adjusted Purchase Index, which was down 0.2 percent compared to the previous week. (The unadjusted Purchase Index increased 6 percent week-over-week, ending the week 35 percent higher than the same time last year.)The slight falloff in application volume accompanied a similarly small increase in mortgage rates. The average interest rate for a 30-year fixed-rate mortgage last week was 4.48 percent, up from 4.46 percent. However, with points falling to 0.31 (including the origination fee), MBA noted the effective rate was actually down from the prior week. November 27, 2013 426 Views Share
January 11, 2010 To continue our report from 1/8/10, the group of art students from the Kansas City Art Institute met with Paolo Soleri for the weekly SCHOOL OF THOUGHT philosophy session. [photo & text: sue] The theme for discussion last week was THE LEAN LINEAR CITY [see a series of postings about the Lean Linear City from Nov. 27. to Dec. 14. 2009]. School of Thought occurs almost every Wednesday at 3 pm and is open to the public and visiting groups. If you plan to attend, please call our visitors center at 928 632-6217 for confirmation. [photo & text: sue] The Kansas City Art Institute group. This photo speaks for itself. [photo: & text: sue]
German sports broadcaster Sport1 will launch its high definition network Sport1+ HD via Sky Deutschland in August after striking a carriage deal with the News Corp-backed pay TV operator.The channel, which is a subsidiary of Constantin Medien, will be available to all HD subscribers to the sports or football Bundesliga package. The channel will air sporting events including the ATP World Tour tennis and motorcycle racing from the the Motorcycle World Championship MotoGP.
We all hear this advice with set-your-clock regularity: “Follow the smart money.” But who or what is this so-called smart money? Why is it smart? How do we find it—let alone try to determine where it’s headed? And how can we take advantage of it? Taking it from the top, what is “smart money”? It’s money put into companies by the top tier of experienced investors, hedge fund managers, and/or institutions. The opposite of it is “dumb money”—the cash that pours in once the investment gets touted front and center in the financial press as “the latest hot secret” for the naïve millions to read—commonly followed by the investing herd stampeding into the sector and driving prices up into a bubble that bursts and leaves heavy losses in its wake. Obviously we want to follow the smart money and avoid getting swept away with the dumb money. But what makes the smart money smart? It’s simple, really. 1. Those in the know have better access to information—and access to better information. If your job were to find the best investments and manage millions, perhaps billions, of dollars, wouldn’t you try to take every advantage the law allows (and maybe even exploit some of the legal gray areas)? This could mean gaining access to policymakers, personally getting to know company management and technical experts, or just immersing yourself in how the market is moving and why. Honestly put, the smart money may know important news hours or even days before it hits the newswires, due to a level of access unavailable to the average retail investor. Using this information, the smart money is able to make better-informed decisions, and make them faster. Sticking with the buy low/sell high mantra is easier when you’re in that position. 2. Serially successful people tend to continue to be successful. The Pareto Principle posits that 80% of an event’s effects often arise from 20% of its causes—or in financial terms, 20% of the people working in a given sector generate 80% of the wins. Being a math guy, I’ll take it one step further. If the top 20% of that group again generates roughly 80% of the wins, this means the top 4% of entrepreneurs generate 64% of the wins. Those who have previously demonstrated that they have what it takes are the ones most likely to do it again. I call it the “4-64” rule. Pay attention to what these folks are doing. 3. They don’t allow the herd to trample them. When you hear about the latest investment fad in the news, you can be pretty sure that idea has passed through hundreds of thousands of hands on its way to you. By the time it hits the airwaves, it’s usually too late: The real money, based on the company’s real value, has already been made. Herd investing is one of the most dangerous threats to your net worth. As the dumb money flows in and the share price begins to climb, it’s easy to get complacent and think that the shares will keep going higher. But that’s when the smart money strikes, pulling out their investment at the expense of the dumb money, taking its profits and leaving the field. Sooner or later, the price takes a nosedive under the selling pressure. It’s the herd that always ends up holding the bag. How to take advantage? Well, let’s take Warren Buffett for example. I have no hesitation labeling him and his group of companies and funds as very smart money. It’s also no secret that Buffett has a cult following, and after it becomes public that he owns a stock, that the “not so smart” money rushes in and pushes that stock even higher. So, the ideal is to get into an investment before the smart money… or at least at the same time. Then, when the involvement of someone like Warren Buffett gets noticed, the herd will drive the price upward, and you will reap the rewards. Of course, you also want to get out before the inevitable decline arrives, which may mean you exit a little early. No problem. You want to preserve your winnings, and no one ever lost money by taking profits. The nice thing is, if it’s basically a sound company, you can ride this cycle multiple times. That’s exactly what we did with ExxonMobil. We got in low, booked our gains, and moved on. It’s now pulled back enough once again that we saw another good entry point, and we jumped back into the stock. But what about our final question? How do you figure out where the smart money is headed next, so that you can get in with or—better yet—just ahead of them? Answer: you do a lot of hard work. There are no shortcuts. You have to ferret out the small number of solid companies that are selling at a discount—and discard all the rest. History is also your guide. It shows that energy stocks move in cycles. We’re somewhere in the trough of a long down cycle, which is exactly the time to go bargain hunting. To maximize our chances of finding the most compelling buys, we’ve now completed a major analysis of the best oil producers and service companies in North America. We’ve locked in our gains before the market selloff on many of the producers, and we believe now is the time to start buying and start building your position in the right companies, during market pullbacks and market weakness. Oil has dropped $15 per barrel in the last year, and majors are sale. Fortune favors the bold, and the key to buying is to do so when others are fearful. This is as true in the oil sector as any other. Buy before the smart money becomes comfortable to stake out major positions. Way before the herd takes notice. And that time is now, in my opinion. Readers who want to make money as the energy sector turns higher—and who want to understand, hedge against, and even profit from the ensuing decline of the petrodollar—are advised to sign up for my Casey Energy Report. For most readers, this is literally a once-in-a-lifetime opportunity. Test my newsletter for the next 3 months, and if you don’t like it or don’t make any money, just cancel within that time for a full and prompt refund. Upon signing up, you’ll receive the September issue of the Casey Energy Report, which will provide you with an in-depth analysis of my favorite companies, including dividend-paying and small-cap companies ready to profit from the Russia/US confrontation that I’ve termed “the Colder War.” So if you want to get behind the real winners, be a part of the “smarter money,” and book some serious profits from the inevitable coming bull market in oil, click here to get started now.
The shelter is prepared to serve up to 1,000 people. Red Cross team leader Jaici Murcia urges residents to stay vigilant and to remember that recovery could be a long road. “Not only is there the immediate disaster, but sometimes in heavily impacted communities, there’s the disaster after the disaster, which is the economic impact.”Murcia says she’s not sure how long the shelter site will be open. The Red Cross has access to the Joel Coliseum until September 26th because of the local fair that’s held on the grounds. If needed, Murcia says they will find another location in the area to help those impacted by the storm.To find the nearest American Red Cross shelter click here.*Follow WFDD’s Keri Brown on Twitter @kerib_news As Florence batters the Carolina coast, thousands of residents have fled the region for shelters farther inland, including here in the Triad.On Friday morning, the Lawrence Joel Veterans Memorial Coliseum in Winston-Salem was home to about 60 evacuees, with Red Cross staff and volunteers providing food, water, medical staff and shower facilities. That number increased to nearly 80 by 2 p.m.Robert Talbot from Wilmington came to seek shelter since a lot of those in his area are full. His family took a bus to get to Winston-Salem. Friends and family say they’re seeing flooding in Wilmington, so his mind is also there.“Some are staying at the shelter, and they are full down there and are sleeping on the floor, and I hear that some places are flooded,” Talbot says. “My vehicle is up there and I don’t know what will happen.”William Mingo from Mooresville was able to get a ride to the shelter. “I left my apartment. Some people went to other shelters and others stayed behind. It concerns me because I have stuff that I’m renting. I have a system and TV, so I’m hoping they will be alright when I get home.”The Red Cross is encouraging volunteers at the Joel Coliseum Shelter to register online. The coliseum is located at 2825 University Parkway in Winston-Salem. KERI BROWN/WFDDHundreds of thousands of people in North Carolina are already without power from Hurricane Florence.Some residents in the Triad anticipate it will happen here too, and they’re not taking any chances. Carrie Russell from Winston-Salem is staying with a family member at the shelter.“My sister is on oxygen 24/7 and we were afraid that if we had a power outage her concentrator wouldn’t give her oxygen and she doesn’t have enough containers to last her one day, so we just want to make sure we have a place to stay and food to eat – and safe.”Officials at the shelter are anticipating the number of evacuees to climb due to the threat of flooding. Sherry Thompson and Cristien Farrior from Winston-Salem came to get shelter for their children.“The power, the flooding, also being able to stay away from the windows and stuff, that’s why I came here,” says Thompson. Farrior adds, “And also, their little needs and stuff. They are going to be hungry and you can’t cook without the power, so it’s best to be here.”Walmart, Krispy Kreme, Deweys and other local businesses have donated food and supplies to the shelter. The Red Cross says it welcomes volunteers and monetary donations. The organization says those who are interested in volunteering their time should register on their website, instead of coming down in person.The organization says anyone who wants to donate clothing or other items should drop them off at the Goodwill located beside the Joel Coliseum on University Parkway and specify that they are for the shelter.Red Cross officials say the Winston-Salem site is also pet-friendly.
One of the country’s most influential disabled campaigners is to take control of BBC Radio’s flagship news programme for its first show of 2016.Baroness [Jane] Campbell (pictured) has been chosen as one of six guest editors who will each take over the Today programme on Radio Four for one day between 28 December and 2 January.For her slot on New Year’s Day, the BBC has said she will examine reform of the House of Lords by asking a new SNP MP to “find out whether working peers can justify their existence”, while also going “head-to-head with Times columnist Matthew Parris on the right to die”.In its announcement of her guest slot, the BBC referred to Baroness Campbell’s background of activism, which helped lead to the Disability Discrimination Act 20 years ago.But Baroness Campbell is also a patron of the National Disability Arts Collection and Archive, and was a co-founder of the National Centre for Independent Living, and has campaigned on independent living issues for most of her adult life, so there are hopes that these subjects could also be aired in the programme.Baroness Campbell told Disability News Service that being a Today guest editor was “a huge privilege and one that carries great responsibility because choosing five or six features, when I have so much to say about the world, was much harder than choosing my Desert Island discs”.She said she could not comment on what issues she had chosen to cover, apart from the two mentioned by the BBC, but added: “I hope listeners (whoever is awake at that time, besides our Labrador, at 6am on New Year’s Day) will appreciate the mix.”Parris has already been interviewed by Baroness Campbell for the 1 January programme about his views, originally expressed in a column in The Spectator, in which he put forward the “Darwinian” argument that “tribes that handicap themselves will not prosper”.He argued in the column in September that “as medical science advances, the cost of prolonging human life way past human usefulness will impose an ever heavier burden on the community for an ever longer proportion of its members’ lives”, and that eventually it will be thought “selfish” to “want to carry on” when life is “fruitless”.Parris wrote about his interview with Baroness Campbell in his Times column this week, admitting that when she asked him if “people like me should be exterminated” his defence was that “we can’t all be in the House of Lords and have vastly expensive help and technology to sustain us”.Other guest editors chosen for the week are cyclist Sir Bradley Wiggins; architect David Adjaye; Lord [John] Browne, former chief executive of BP; actor Michael Sheen; and lawyer Miriam González Durántez.
Senior Editor –shares Matthew Humphries Tesla Tesla Stops Selling $35,000 Model 3 Online 2019 Entrepreneur 360 List Tesla has been streamlining its vehicle options of late in a bid to make things simpler for consumers and optimized for production. More changes happened this week and it’s now no longer possible to buy the $35,000 Model 3 online.We’ve already lost the standard range Model S and the Model 3 Mid Range battery option got dropped. Prices have also gone up. Yesterday, further updates were introduced as detailed on the Tesla blog.Autopilot is now a standard feature on all vehicles, but importantly, it’s being added for a lower cost than the Autopilot option use to command. For example, Autopilot used to cost $3,000 when added to the $37,500 Model 3 Stand Plus, but now it comes as standard for $39,500.As to why Autopilot is now a standard feature, Tesla explains that, “our data strongly indicates that the chance of an accident is much lower when Autopilot is enabled. Autopilot also dramatically improves the quality of the driving experience, especially in heavy traffic, as thousands of our customers frequently describe online”As for the $35,000 Model 3. It can no longer be purchased online, but that doesn’t mean it isn’t available. Tesla explains that the now $39,500 Model 3 Standard Plus “has sold at more than six times the rate of Standard,” so the decision was made to simplify production and focus on the Standard Plus. It means the $35,000 Standard Model 3 will now be sold as a software-limited version of the Standard Plus. Ordering one requires a call or visit to a Tesla store.A software-limited Standard Plus means the range is reduced by 10 percent and onboard music streaming service, navigation with live traffic visualization, and heated seats features are disabled. However, they can be enabled with an upgrade if the owner so wishes. You can also do the opposite and downgrade a Standard Plus to Standard features and receive a refund on the price difference, which is a welcome offer and a nice touch. A call or visit to a Tesla store is also required if you want the Model 3 Long Range Rear-Wheel Drive configuration.Finally, Tesla is introducing leasing for the Model 3 in the US. There will be 10,000, 12,000, and 15,000 annual mileage plans with a “small down payment and competitive monthly payments.” Interestingly, Tesla says anyone who leases a Model 3 won’t be able to purchase the vehicle at the end of the lease because Tesla intends to use them as part of a ride-hailing network when full-autonomy becomes a realistic option. Add to Queue Next Article This story originally appeared on PCMag The only list that measures privately-held company performance across multiple dimensions—not just revenue. The vehicle lineup Tesla offers has been given an overhaul. April 12, 2019 3 min read Image credit: via PC Mag Apply Now »
October 3, 2014 Data Breach Add to Queue 3 min read Reuters Free Webinar | July 31: Secrets to Running a Successful Family Business Names, addresses, phone numbers and email addresses of the holders of some 83 million households and small business accounts were exposed when computer systems at JPMorgan Chase & Co were recently compromised by hackers, making it one of the biggest data breaches in history.The bank revealed the scope of the previously disclosed breach on Thursday, saying that there was no evidence that account numbers, passwords, user IDs, birth dates or Social Security numbers had been stolen.It added that it has not seen “unusual customer fraud” related to the attack which exposed contact information for 76 million households and 7 million small businesses.The people affected are mostly account holders, but may also include former account holders and others who entered their contact information at the bank’s online and mobile sites, according to a bank spokeswoman.Security experts outside of the bank warned that the breach could result in an increase in crime as scammers will likely attempt to use the stolen information to engage in various types of fraud.The bank’s customers should be on heightened alert for fraud, said Mark Rasch, a former federal cyber crimes prosecutor.”All of this data is useful to hackers and identity thieves,” he said. “The kind of information that was stolen is not sensitive itself, but is frequently used to validate people’s identities.”Tal Klein, vice president with the cybersecurity firm Adallom, said that the breach could undermine confidence in the security of banks and other companies that people assume are well protected from hackers.”Criminals could literally take on the identities of these 83 million businesses and people. That’s the biggest concern,” he said.”Until now the assumption has been that the companies that get breached are the ones that have poor security practices, but we know that JPMorgan had a good security program and that they invest heavily in this area,” he said. “So what we are waking up to is that the fundamental nature of security is broken.”Still, JPMorgan advised customers on its website that it does not believe they need to change their passwords or account information.Company spokeswoman Patricia Wexler said that the bank is not offering credit monitoring to its customers because no financial information, account data or personally identifiable information was compromised.At the end of August, JPMorgan said it was working with U.S. law enforcement authorities to investigate a possible cyber attack. As with home break-ins, it can take victims of data attacks months to discover what, if anything, is missing.(Reporting by Tanya Agrawal in Bangalore, David Henry in New York and Jim Finkle in Boston.; Editing by Ted Kerr and Bernard Orr) JPMorgan Hack Exposed Data of 83 Million Homes and Small Businesses This story originally appeared on Reuters Next Article Register Now » –shares Learn how to successfully navigate family business dynamics and build businesses that excel.
Add to Queue Office-supply chains Staples Inc and Office Depot Inc are in advanced talks to merge, the Wall Street Journal reported, citing people familiar with the matter.The price and structure of the proposed deal couldn’t be learned and there is no guarantee a deal will be reached, the newspaper reported.Staples has a market value of about $11 billion, while Office Depot has a market value of about $4.1 billion.Last month, activist investor Starboard Value LP called for the two companies to merge, saying a combined entity would lead to greater savings.A merger would help fend off intense competition from online retailers such as Amazon.com Inc and big-box chains such as Wal-Mart Stores Inc that sell the same core office supplies, such as paper and ink toner, for less.The combination of the two would likely get a close look from antitrust regulators, the Journal said.Office Depot and Staples were not immediately available for comment outside regular U.S. business hours.Regulators nixed Staples’ attempt to buy Office Depot in 1997, citing antitrust concerns.The FTC approved Office Depot’s $976 million acquisition of OfficeMax in 2013 without the need to close stores, citing increased competition in the office supply industry.(Reporting by Supriya Kurane in Bengaluru; Editing by Gopakumar Warrier) Reuters –shares Mergers Register Now » Next Article Free Webinar | July 31: Secrets to Running a Successful Family Business This story originally appeared on Reuters February 3, 2015 Staples, Office Depot in Advanced Talks to Merge 2 min read Learn how to successfully navigate family business dynamics and build businesses that excel.
Reviewed by James Ives, M.Psych. (Editor)Nov 2 2018City of Hope, a world-renowned independent cancer research and treatment center, and its affiliate, Translational Genomics Research Institute (TGen), have announced a letter of intent to develop a state-of-the-art cell therapy manufacturing facility in the Phoenix Metropolitan Area, a move that would improve the speed at which stem cell research and cancer treatment is delivered.The Phoenix facility would model City of Hope’s three Current Good Manufacturing Practice (cGMP) facilities in Duarte, California, which have produced well over 1,300 cell and gene therapy products and oncology drugs for many cancer clinical trials across the nation. City of Hope is one of a small number of select cancer centers in the U.S. to provide both biological and chemical GMP manufacturing at a single institution. Its facilities have the ability to produce both gene therapy viruses and cells needed for CAR T therapies.”City of Hope is dedicated to innovation in biomedical science and has one of the most comprehensive CAR T cell programs in the world with 16 ongoing CAR T clinical trials,” said Robert W. Stone, president and chief executive officer of City of Hope as well as vice chairman of the TGen board of directors. “Cancer patients need effective treatments now. City of Hope and TGen are working to quickly move effective therapies from the laboratory to patients’ bedside. Additional cGMP facilities will help us expand our capabilities to serve people in Arizona and across the nation.”Demand for clinical cell therapies is expected to grow 42 percent annually over the next decade, according to “Cell Therapy Manufacturing Market.” Most cell therapy manufacturing facilities are at capacity or over capacity because demand is outpacing production rates.”This significant investment further enhances Arizona’s reputation as a hub for bioscience and health care innovation,” said Arizona Governor Doug Ducey. “Our state offers a strong concentration of talent ready to meet the needs of this facility. The work being conducted by City of Hope and TGen is critical in the fight against cancer, and Arizona is proud to play a role in it.”Related StoriesExciting study shows how centrioles center the process of cell divisionNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’The planned facility would meet an urgent need of accelerating cures for patients in Arizona, Southern California and elsewhere. The facility would also provide additional opportunities to partner and collaborate with scientists in Arizona, an important objective for TGen, an affiliate of City of Hope.At this future facility, chimeric antigen receptor (CAR) T cells, which have demonstrated durable cancer remission in blood cancers such as leukemia and lymphoma, would be among the cells that are produced. The new facility could also support the cell therapy production needs of pharmaceutical and biotechnology companies who need this kind of specialized GMP capability to move clinical trial programs forward.”The road to future cancer cures requires genomic-enabled medicine and the type of immune-system enhancements that would result from this cell therapy manufacturing facility, which will provide local access to new treatments for Arizona patients,” said Jeffrey Trent, Ph.D., TGen president and research director. “City of Hope’s clinical and manufacturing expertise in immunotherapy is at the forefront of this field, and combined with TGen’s genomic testing, offers patients new hope for their future.”The Arizona Commerce Authority will work in partnership with City of Hope and TGen to provide workforce development assistance through its Navigator and local One-Stop programs.Source: https://www.cityofhope.org/news/city-of-hope-and-tgen-announce-cell-therapy-facility
Reviewed by Kate Anderton, B.Sc. (Editor)May 9 2019Teens who experience cyberbullying are more likely to suffer from poor sleep, which in turn raises levels of depression, found a University at Buffalo study.Although research has examined the relationship between online bullying and depression, the UB study is one of few to explore the connection between cyber victimization and sleep quality.The study surveyed more than 800 adolescents for sleep quality, cyber aggression and depression.The research will be presented by Misol Kwon, first author and doctoral student in the UB School of Nursing, at SLEEP 2019, the 33rd annual meeting of the Associated Professional Sleep Societies in San Antonio, Texas from June 8-12.Related StoriesSocial media use and television viewing linked to rise in adolescent depressive symptomsNew structured approach to managing patients with depression in primary careNovel bed system with VR brainwave-control for sleep bliss”Cyber victimization on the internet and social media is a unique form of peer victimization and an emerging mental health concern among teens who are digital natives,” said Kwon. “Understanding these associations supports the need to provide sleep hygiene education and risk prevention and interventions to mistreated kids who show signs and symptoms of depression.”Nearly one third of teens have experienced symptoms of depression, which, in addition to changes in sleep pattern, include persistent irritability, anger and social withdrawal, according to the U.S. Office of Adolescent Health.And nearly 15 percent of U.S. high school students report being bullied electronically, says Kwon. At severe levels, depression may lead to disrupted school performance, harmed relationships or suicide.The risks of allowing depression to worsen highlight the need for researchers and clinicians to understand and target sleep quality and other risk factors that have the potential to exacerbate the disorder.The research was supported by a $1.8 million grant from the National Institute on Alcohol Abuse and Alcoholism in the National Institutes of Health awarded to Jennifer Livingston, PhD, principal investigator and associate professor in the UB School of Nursing.Additional UB School of Nursing investigators include Suzanne Dickerson, DNS, professor and chair of the Department of Biobehavioral Health and Clinical Sciences; and Eunhee Park, PhD, assistant professor. Young Seo, doctoral candidate in the UB Graduate School of Education, is also an investigator. Source:http://www.buffalo.edu/news/releases/2019/05/012.html
Reviewed by James Ives, M.Psych. (Editor)May 30 2019What if wearing a blood pressure cuff could help prevent stroke? In a new study, people who restricted their blood flow by wearing inflated blood pressure cuffs on an arm and leg showed signs of more controlled blood flow to their brain, a process that could be protective if blood flow is more severely restricted in the event of a stroke, according at a study published in the May 29, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.The process is called remote ischemic preconditioning. Previous studies have shown that remote ischemic preconditioning, using compression on the extremities to repeatedly restrict blood flow and the oxygen it carries, is beneficial to internal organs like the heart, making them more resilient and resistant to changes in blood flow and the serious damage that can occur during a heart attack when tissue is first deprived of oxygen and then damaged when oxygen is restored. Since previous studies have shown benefits to the heart, we wanted to determine if remote ischemic preconditioning could also be beneficial to the brain. Our study found such preconditioning temporarily improved dynamic cerebral autoregulation, which is the brain’s ability to regulate and ensure adequate blood flow to the brain despite blood pressure changes. We also found an increase in biomarkers in the blood that can be protective to the nervous system and brain.”Study author Yi Yang, MD, PhD, of the First Hospital of Jilin University in Changchun, China The study involved 50 people with an average age of 35 who were all in good health. Each person was monitored twice, for 24 hours each time, first without preconditioning and then with preconditioning.Each participant went through the preconditioning process once, with blood pressure cuffs placed on one upper arm and one thigh. The cuffs were inflated for five minutes and then deflated for five minutes. This process to reduce blood flow was repeated four times.Researchers measured each participant’s brain blood flow regulation by measuring blood pressure and also using ultrasound to measure blood flow within two main arteries in the brain. Measurements were taken at the start of each day and then at six additional time points throughout each 24-hour time period.Related StoriesResearch team to create new technology for tackling concussionNeural pathways explain the relationship between imagination and willingness to helpWearing a hearing aid may mitigate dementia riskThey found that after preconditioning, participants had improved brain blood flow regulation starting six hours after preconditioning that was sustained for at least 24 hours.Researchers also measured biomarkers in the blood one hour after preconditioning and found that after preconditioning, participants had an increase in two biomarkers known to protect the nervous system, as well as an increase in four biomarkers involved in the inflammatory process in the immune system. They also found lower levels of a biomarker that responds to inflammation.”Our results showed an increase in one biomarker called glial cell line-derived neurotrophic factor that has been previously shown to provide protection not only against diseases such as stroke, but also against other nerve-related diseases like Parkinson’s disease and epilepsy,” said Yang. “Therefore, our results suggest that remote ischemic preconditioning may increase such protective biomarkers and may be beneficial in preventing a number of neurological diseases.”Glial cell line-derived neurotrophic factor increased from an average of 0.289 picograms per milliliter (pg/ml) to an average of 0.789 pg/ml one hour after preconditioning.Yang said: While our results are exciting, obviously we can’t know when someone will have a stroke and when this could be beneficial. We hope to use these results to help develop a new medication or treatment that will help all people better resist stroke or other neurological diseases. It’s important to emphasize that people should not try to restrict blood flow on their own because, unless under the care of a physician, they could cause themselves harm. In addition, our study was small and much more research needs to be done to confirm our findings before recommendations can be made to physicians to use such preconditioning as a therapy.” One limitation of the study is that blood samples were taken only once. Another limitation is that participants were healthy, so the results may be different in people who have risk factors for stroke or other diseases.Source: American Academy of Neurology
Provided by CORDIS Credit: sylvrob1, Shutterstock Pedal power: the rise of cargo bikes in Germany Explore further The Horizon 2020 TiMMi Transport project has developed an online ride-sharing platform for inner-city deliveries that offers a high level of service while minimising environmental impacts. “The platform connects ‘job requesters’ who need their goods transported, such as package companies, online shops, laboratories and private individuals, with ‘transporters’, professional bike couriers who know how to do emission-free delivery, fast!” says project coordinator Dr. Christina Kleinau.Increased capacity A mobile web app that allows registered users to upload and accept delivery jobs is at the heart of TiMMi Transport’s success. To upload a job, requesters enter details like the dimensions of the package, pick-up and delivery addresses, and their contact information. The TiMMi system also has open interfaces to web shops and other internal systems so that jobs can be automatically submitted en masse. The job details are then displayed online, to be accepted by the network of professional bike couriers, who are connected to the platform. Transporters receive notifications about jobs in their area, and if they accept one, the contact details of the sender and the recipient are exchanged privately. When a job is completed, the courier marks the job as done and the delivery confirmation is submitted back to the job requester.It has long been known that bicycles are the quickest way to move goods from A to B within an urban environment. Until recently, there has not been a technically advanced system for the bike courier companies to coordinate orders from diverse mediums and locations. Now with the TiMMi system, bike couriers can receive orders from an online form, and online retail customers can select the CO2-free express delivery option for their purchase.The future of logistics – cargo bikesThe project has developed a business relationship with some of Germany’s largest logistics companies and conducted tests on last-mile package delivery using large volume cargo bikes. “The test projects successfully proved the feasibility of cargo bikes, reducing pollutant emissions in inner-city areas. We are now discussing the best way to implement bike delivery on a wider scale,” comments Dr. Kleinau. A lot is possible using large-volume cargo trikes and bike trailers, which can carry up to 250 kg, or a volume of 1.7 m3. TiMMi Transport is set to become the inner-city delivery service of choice, firstly for the ethical consumption sector, but also as a mainstream solution as climate protection becomes standard. “Approximately 20 percent of customers we deliver to express their appreciation of being delivered to by bike, instead of by van. The network of businesses we deliver for will be continually expanded to maximise the economic and ecological efficiency of the TiMMi network. We will also continue to expand and look forward to operating the service in international locations,” concludes Dr. Kleinau. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. City centres are becoming increasingly congested by traffic, many of which are delivery vehicles. An EU-funded project has developed a solution for delivering packages that reduces traffic and eliminates carbon dioxide (CO2) and other harmful emissions. Citation: Online platform for carbon dioxide-free deliveries (2018, December 10) retrieved 17 July 2019 from https://phys.org/news/2018-12-online-platform-carbon-dioxide-free-deliveries.html
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a video surfaced online of the Toronto mayor in a diner called Steak Queen, which will be important,” he said.- Donald J Trump (@realDonaldTrump) May 16 2017The tensions between the upper echelons of the Trump administration and the intelligence agencies – most notably the FBI – have been a major feature of the opening months of his tenure on Pennsylvania AvenueHis tweets about the meeting were in direct contrast to comments made yesterday by HR McMaster a national security adviser to the President who said: "What Im saying is that the premise of the article was false – that in any way the president had a conversation that was inappropriate or that resulted in any kind of lapse in national security" referring to an article in the Washington Post that accused Trump of sharing secretsCredit: PAThe Washington Post article alleged that Trump had given away information that was classified and came from a third party – later reported as being Jordan or Israel – that had not consented to it being shared with Russia Under US intelligence law it is illegal for the majority of US government actors to give away classified information to a hostile nation – which would include Russia – although as President Trump can declassify informationSource: Washington Post Haaretz Featured Image Credit: PA Topics: RussiaA man who Rihanna has named as her cousin has been shot and killed just hours after they spent Christmas together in Barbados Twenty-one-year-old Tavon Kaiseen Alleyne was taking a walk at 7pm on Boxing Day in St Michaels when he was shot several times by an unidentified male who then fled the scene according to Nation News He was rushed into hospital but later died due to his injuries Rihanna has not confirmed the events which led to her apparent family members deathPolice are currently looking for the gunman and have asked for anyone who may have any information to get in touch Credit: Instagram/Tavon Kaiseen AlleyneSinger Rihanna paid a heart-breaking tribute on Instagram sharing a number of photos of them together she wrote: "RIP cousin.38% higher than todays opening trades for Apple, Icahn also wants Apples board to undertake a push larger share buyback than the $50 billion package that is currently approved (which followed an $80 billion buyback for which Icahn had agitated). In fact, "We need to introduce personal responsibility so that fans who violate rules start being denied the right to go to stadiums and support their teams.
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