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Bob Weir To Join Dumpstaphunk Tonight For Annual Halloween Show

first_imgDumpstaphunk will return to Sweetwater Music Hall tonight for their annual Halloween celebration in Mill Valley, CA. For the second year in a row, Grateful Dead guitarist Bob Weir will join the New Orleans funk masters for a night of mischief music, alongside the Jazz Mafia Horns. In 2016, Weir joined Dumpstaphunk for a “Shakedown Street >Dear Prudence > Iko Iko > Big Chief New Orleans Medley > Knockin’ on Heavens Door” medley that kept fans dancing all night long. There’s no telling what will go down tonight, but the band warns fans to come on out and “find out what tricks n treats we gonna pull outta the Dumpsta!!”There is a limited supply of tickets left here.Check out a taste of what’s to come in the video below, from last year’s “Shakedown Street”:last_img read more

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Converting skin cells to stem cells creates ‘kidney structures’

first_imgHarvard Stem Cell Institute (HSCI) principal faculty at Brigham and Women’s Hospital (BWH) have established a highly efficient method for making kidney structures from stem cells derived from skin taken from patients. The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, and the effects of toxic drugs, and could be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury. In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient’s own cells.The work was published in Nature Biotechnology.“Kidneys are the most commonly transplanted organs, but demand far outweighs supply,” said co-corresponding author Ryuji Morizane, associate biologist in BWH’s Renal Division. Morizane worked in collaboration with HSCI researchers Joseph Bonventre, Albert Lam, and M. Todd Valerius.“We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells into kidney structures that resemble those found in a normal human kidney,” Morizane said. “We’re hopeful that this finding will pave the way for the future creation of kidney tissues that could function in a patient and eliminate the need for transplantation from a donor.”Chronic kidney disease (CKD) affects 9 to11 percent of the U.S. adult population and is a serious public health problem worldwide. Central to the progression of CKD is the gradual and irreversible loss of nephrons, the individual functional units of the kidney. Patients with end-stage kidney disease benefit from treatments such as dialysis and kidney transplantation, but these approaches have several limitations, including the limited supply of compatible organ donors.While the human kidney does have some capacity to repair itself after injury, it is not able to regenerate new nephrons. In previous studies, researchers have successfully differentiated stem cells into heart, liver, pancreas, or nerve cells by adding certain chemicals, but kidney cells have proven challenging. Using normal kidney development as a roadmap, the investigators developed an efficient method of creating kidney precursor cells that self-assemble into structures that mimic complex structures of the kidney. The research team further tested these organoids — three-dimensional organ structures grown in the lab — and found that they could be used to model kidney development and susceptibility of the kidney tissue to therapeutic drug toxicity. The kidney structures also have the potential to facilitate further studies of how abnormalities occur as the human kidney develops in the uterus and to establish models of disease in which they can be used to test new therapies.“This new finding could hasten progress to model human disease, find new therapeutic agents, identify patient-specific susceptibility to toxicity of drugs, and may one day result in replacement of human kidney tissue in patients with kidney disease from cells derived from that same patient,” said Bonventre, an HSCI principal faculty member. “This approach is especially attractive because the tissues obtained would be ‘personalized’ and, because of their genetic identity to the patient from whom they were derived, this approach may ultimately lead to tissue replacement without the need for suppression of the immune system.”last_img read more

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WADA ready to wipe out drug cheats, chief says

first_img Read Also: Australian Open: Sharapova says there’s still a lot of fire amid wildcard offer The significant extent of state-sponsored doping in Russia, notably between 2011 and 2015, was revealed in an independent report by sports lawyer Richard McLaren, released in 2016. The issue has dealt a colossal blow to the status of post-Soviet Russia as a major sports power after hosting events such as the 2013 World Athletics Championships, the 2014 Winter Olympics in Sochi and the 2018 World Cup. The Sochi Games later became notorious for the number of doping violations by prominent Russian athletes. FacebookTwitterWhatsAppEmail分享 Outgoing WADA President Craig Reedie says the Russian doping scandal shows that clean sport is under attack, but the anti-doping organization now has the tools to better weed out drug cheats. Taking stock of his six years at the helm of the World Anti-Doping Agency, the 78-year-old Briton insists the group is “stronger” than ever as it faces the “unprecedented” challenge of the doping crisis in Russia. Outgoing WADA President Craig Reedie says the Russian doping crisis is the biggest challenge he has faced in his six years at the helm of the anti-doping agency “Considering the last six years in particular, I am especially pleased to see how WADA responded to the challenges it faced since 2014, in particular the Russian doping crisis,” he said in his end-of-term message. The crisis, he recalled, led to the creation within WADA of an “intelligence and investigations” service, which played “a decisive role” in the recent decision to exclude Russia from major world sports competitions for falsifying anti-doping data. The Russian anti-doping agency RUSADA announced Friday that it has challenged the exclusion. Ultimately, it will be up to the Court of Arbitration for Sport to rule on the matter, said Reedie, whose term officially ends Tuesday. “Throughout this process WADA has shown it has the will, the expertise and the legal tools to stand up effectively to this unprecedented level of cheating and corruption,” he said. WADA decided on December 9 to ban Russia from participating in major international events for four years, including the 2020 and 2022 Olympic Games and the 2022 World Cup. Loading… Promoted ContentCelebrities Showing Support For George Floyd ProtestsBirds Enjoy Living In A Gallery Space Created For ThemHere Are The Top 10 Tiniest Mobile Phones On The Planet!11 Most Immersive Game To Play On Your Table TopWhy Go Veg? 7 Reasons To Do ThisThis Guy Photoshopped Himself Into Celeb Pics And It’s HystericalCouples Who Celebrated Their Union In A Unique, Unforgettable Way10 Phones That Can Work For Weeks Without Recharging5 Of The World’s Most Unique Theme ParksLittle Georgie Henley Has Grown Into A Beautiful Swan!14 Hilarious Comics Made By Women You Need To Follow Right NowIs Cristiano Ronaldo Converting His Hotels To Hospitals? Only handpicked Russian athletes will be able to participate in the competitions, but under a neutral flag and without the national anthem being played. WADA estimated that Russia had “manipulated” the data of the Moscow anti-doping laboratory which were transmitted to it at the beginning of the year, an umpteenth rebound in a scandal which started with the revelation in 2015 of an institutional doping practiced since 2011 and involving senior officials, secret agents and trafficked urine vials.last_img read more