The National Association of Master Bakers (NAMB) has teamed up with California Raisins to offer two one-day craft courses for Christmas.The courses will be delivered by Ian Wilson of the Village Bakery at Slattery Patisserie & Chocolatier in Manchester on 5 November and at Bako Western in Cullompton, Devon, on 12 November. The courses are free to NAMB members and cost £50 for non-members, which includes tuition, lunch and refreshments.The breads and Christmas confectionery to be made during the courses include Stollen according to a traditional German recipe, gluten-free Cinnamon Stars, a “Taste of Christmas” bread using spelt and a “Gingerbread House”. Demand for places is expected to be high and anyone interested in attending should return the booking form to NAMB, 21 Baldock Street, Ware, Hertfordshire SG12 9DH or email: [email protected]
Jam stalwarts moe. continued their winter tour last night with a tight two-set performance at the Georgia Theatre in Athens, GA. The band filled the show with older, fan favorite material, awesome and poignant covers, ambitious improvisation and slick transitions.Set one opened with an energetic take on “Sensory Deprivation Bank”. “All Roads Lead to Home” followed, before a fun version of “Queen of Everything” was trotted out. “Don’t Wanna Be” came next, before an awesome “Opium” into “New York City” segment that was the highlight of the first set. A big “McBain” brought the first set to a close.Set two started off with the familiar falsetto of “Blue Jeans Pizza”. A heartfelt “The Happiest Days Of Our Lives” was up next, and that started off an awesome three-song segment that featured Pink Floyd‘s ever-poignant “Another Brick in the Wall”, and a raucous “Lazarus”. The band then kicked into high-gear with a seamless, four-song set-closing run through “Hi and Lo”, “Don’t Fuck With Flo”, “Ricky Marten”, and “Meat”.For the encore, the band stepped on the stage and busted out an improv-heavy cover of the Allman Brothers‘ classic “In Memory Of Elizabeth Reed”. It was a touching tribute to the recently deceased Butch Trucks, who sadly passed away earlier this week. They turned in an emotional version of “Liz Reed” in honor of their fallen compadre, as they toured with the Allman’s back in the 2000s.See below for a full setlist from last night’s moe. show at the Georgia Theatre. Catch moe. at their next tour stop at the Bijou Theatre in Knoxville, TN on Tuesday, January 31st.moe. | Georgia Theatre | Athens, GA | 1/28/2017Set One: Sensory Deprivation Bank, All Roads Lead to Home, Queen of Everything, Don’t Wanna Be, Opium> New York City, McBainSet Two: Blue Jeans Pizza, The Happiest Days Of Our Lives > Another Brick in the Wall> Lazarus, Hi and Lo> Don’t Fuck With Flo> Ricky Marten> MeatEncore: In Memory Of Elizabeth Reed
Harvard Stem Cell Institute (HSCI) principal faculty at Brigham and Women’s Hospital (BWH) have established a highly efficient method for making kidney structures from stem cells derived from skin taken from patients. The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, and the effects of toxic drugs, and could be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury. In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient’s own cells.The work was published in Nature Biotechnology.“Kidneys are the most commonly transplanted organs, but demand far outweighs supply,” said co-corresponding author Ryuji Morizane, associate biologist in BWH’s Renal Division. Morizane worked in collaboration with HSCI researchers Joseph Bonventre, Albert Lam, and M. Todd Valerius.“We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells into kidney structures that resemble those found in a normal human kidney,” Morizane said. “We’re hopeful that this finding will pave the way for the future creation of kidney tissues that could function in a patient and eliminate the need for transplantation from a donor.”Chronic kidney disease (CKD) affects 9 to11 percent of the U.S. adult population and is a serious public health problem worldwide. Central to the progression of CKD is the gradual and irreversible loss of nephrons, the individual functional units of the kidney. Patients with end-stage kidney disease benefit from treatments such as dialysis and kidney transplantation, but these approaches have several limitations, including the limited supply of compatible organ donors.While the human kidney does have some capacity to repair itself after injury, it is not able to regenerate new nephrons. In previous studies, researchers have successfully differentiated stem cells into heart, liver, pancreas, or nerve cells by adding certain chemicals, but kidney cells have proven challenging. Using normal kidney development as a roadmap, the investigators developed an efficient method of creating kidney precursor cells that self-assemble into structures that mimic complex structures of the kidney. The research team further tested these organoids — three-dimensional organ structures grown in the lab — and found that they could be used to model kidney development and susceptibility of the kidney tissue to therapeutic drug toxicity. The kidney structures also have the potential to facilitate further studies of how abnormalities occur as the human kidney develops in the uterus and to establish models of disease in which they can be used to test new therapies.“This new finding could hasten progress to model human disease, find new therapeutic agents, identify patient-specific susceptibility to toxicity of drugs, and may one day result in replacement of human kidney tissue in patients with kidney disease from cells derived from that same patient,” said Bonventre, an HSCI principal faculty member. “This approach is especially attractive because the tissues obtained would be ‘personalized’ and, because of their genetic identity to the patient from whom they were derived, this approach may ultimately lead to tissue replacement without the need for suppression of the immune system.”
FacebookTwitterLinkedInEmailPrint分享S&P Global Market Intelligence ($):Bowie Resource Partners LLC could face a liquidity shortfall in the next year if it fails to extend its revolving credit facility, S&P Global Ratings said in a downgrade of the U.S. coal producer.The company’s liquidity may be insufficient to cover its revolver due in August and mandatory amortizations, a June 8 ratings action said. S&P Global Ratings dropped its corporate credit rating for Bowie from “CCC+” to “CCC,” lowered the rating on the company’s $335 million first-lien and $100 million second-lien term loans to “B-” and “CC” from “B” and “CCC” and placed all ratings on CreditWatch with negative implications.“While long-term contracts with large utility customers provide some stability to future cash flows, we view the business to be vulnerable to unexpected outages or operational disruptions given its smaller size and dependence on two anchor customers,” the rating agency wrote.More ($): Bowie Resource Partners downgraded over concerns of liquidity shortfall Ratings downgrade as U.S. coal company Bowie Resource Partners faces ‘liquidity shortfall’
Charlottesville runners have always flocked to Walnut Creek Park’s scenic, rolling singletrack. Now, Walnut Creek Park is home to a new ultra—the Thomas Jefferson 100K.Beginning at 5 a.m. on March 15, runners will complete seven 8.9-mile loops of the park. The multi-loop course provides spectators and supporters with easy access, making it ideal for first-time ultra runners. But the steep, rugged singletrack and competitive field will provide plenty of challenge for seasoned ultrarunners, too.The race is organized by elite ultrarunning star Andy Jones-Wilkins, a Western States 100 legend and nationally renowned athlete who has run more than 80 ultras and 29 100-mile races.The 62-mile race has 1,000 feet of elevation change per loop (7,000 total). There are aid stations at the start/finish and roughly the halfway point of each 8.9-mile loop, so runners never go more than 5 miles without support.Proceeds from the race go directly to the trails of Walnut Creek Park and the county park system.If you’re looking for a beautiful, breathtaking new ultra, TJ is where you want to be. Run Thomas Jefferson’s backyard this spring and test your limits at this up-and-coming ultra classic.View course maps and register at tj100k.com
Topics : “So right now we are sitting in pretty strict self-isolation. All our groceries are delivered, everything we need is contact-free delivery and we don’t go outside,” Muratova said on a call, adding the plan is to do so at least until July.”The main thing for me is that I can be with a girl friend here,” Nina, also on the video call, said.They are cooking together and finding activities for Nina to do, Muratova said, adding that Nina was enjoying having her own space for the first time and being able to take showers alone, rather than in groups.”Unexpectedly positive outcomes””All over the country, institutions house hundreds, sometimes thousands of people in one place … If one gets sick with coronavirus, so will everyone else,” Lida Moniava, director of a Moscow children’s hospice, said.In a call with regional governors on Friday, President Vladimir Putin said if such outbreaks occurred, it was due to a failure of leadership: “Outbreaks, as a rule, occur as a result of our incomplete work. Because we have missed something.”Last week, a psychiatric hospital in Russia’s northern city of Arkhangelsk reported an outbreak of 79 coronavirus cases. Two facilities housing children with special needs went into lockdown this week in Siberia’s Chelyabinsk region after staff members tested positive for COVID-19, Interfax reported.”It’s terrifying, but sometimes terrifying situations can produce unexpectedly positive outcomes,” Moniava said, referring to the new government policy.”Thanks to the coronavirus, an event occurred that is unprecedented in the whole adult and child boarding house system … The doors of these institutions were thrown open.”Five staff members at Moniava’s Lighthouse Charity Foundation have taken in severely physically disabled children home from two Moscow city orphanages for the quarantine period.Medical beds rigged with all the necessary equipment to support the children’s breathing and movement were installed in their homes, and the orphanage set up a WhatsApp chat group to provide medical advice and tips to the children’s new hosts.Moniava said the paperwork granting temporary adoption rights was handled by authorities within a day.Vica Lobanova, a 28-year-old editor working remotely during Moscow’s lockdown, who offered to share her home with Svetlana, from the same psychiatric ward in Elk Island park, said that in their case the paperwork was more arduous.Delays brought Svetlana, who knew of the spread of the coronavirus from the news shown on a television in the ward, to tears. With around 100 people on her building’s floor, keeping a safe distance would have been tough.Now self-isolating in Lobanova’s flat, Svetlana, who has been in institutions since her early teens, spends time playing with Lobanova’s dog and taking online classes.”I gave Sveta one of my two laptops and it has Zoom and Sveta knows her schedule, puts in the conference number herself,” Lobanova, who also volunteers with Life Route, said, adding that the decision was a straightforward one for her.”I live alone, I have a one bedroom flat … so I have space,” Lobanova said. Concerned about how fast the coronavirus could spread in the densely populated ward, Muratova decided to use a new government emergency measure allowing people to take residents of state institutions home during the lockdown to get Nina out.Muratova, a 30-year-old marketing researcher, already had a flatmate, so she moved into temporary accommodation provided by her volunteer group, the Life Route foundation.Nina, who has spent her life in children’s homes and then the psychiatric hospital, moved in with Muratova the next day.With Moscow in a partial lockdown, the two women are self-isolating, and as Nina’s disability means she is not considered to have legal status, they are unsure how to register her for a digital pass allowing some excursions outside. Moscow resident Arina Muratova knew something was wrong when the messages she received from Nina, a patient at Psychiatric Hospital No.22 who has become a friend during her voluntary work there, suddenly lost their usual, optimistic ring.The hospital had gone into a precautionary lockdown, aimed at preventing the spread of the new coronavirus, and Nina, 26, was feeling more confined than ever.”They were already living in isolation,” Muratova, who has volunteered for three years at the hospital in the city’s Elk Island park, said. “Now their [living space] had been shrunk to a tiny cube.”
Ian Wright reacts to ‘beautiful’ Alexandre Lacazette and Pierre-Emerick Aubameyang behaviour Comment Metro Sport ReporterMonday 11 Mar 2019 1:01 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link Advertisement Aubameyang and Lacazette have scored 34 goals between them this season (Picture: Getty)Ian Wright has heaped praise on Arsenal strike duo Alexandre Lacazette and Pierre-Emerick Aubameyang, branding their interaction with one another against Manchester United on Sunday as “beautiful”.The Gunners beat the Red Devils in impressive fashion on Sunday, with the latter of the two strikers scoring the club’s second goal from the penalty spot to secure a 2-0 win.However, before the penalty, Lacazette gave his team-mate a little encouragement and asked him to forget the other recent high-pressure spotkick his missed against Tottenham a week earlier.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City‘The way Lacazette gave the penalty to Aubameyang and gave him that little speech about taking that and scoring, what what it will do for him, it was a beautiful thing to see,’ Wright said on his YouTube channel.AdvertisementAdvertisementADVERTISEMENT‘Last week after the Tottenham game, people were saying Aubameyang should be sold because he missed a penalty against Tottenham. And now this week he’s score a goal against Manchester United from the penalty spot.‘Let’s face it, his demeanour in the way he took the penalty was exactly the same. It’s not like he was doing anything flash against Tottenham, that’s how he takes them.More: Manchester United FCRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseEx-Man Utd coach blasts Ed Woodward for two key transfer errors‘I’m very pleased with the outcome. I was very nervous about the game. Now all we have got to do is get behind the boys for Rennes.’Arsenal take on the Ligue 1 club in the Europa League on Thursday as Unai Emery’s side look to overcome a 1-3 aggregate scoreline.They then take on Newcastle on April 1 as they look to maintain their fourth spot in the Premier League.MORE: Wright praises Solskjaer for making Ozil ‘disappear’ against Man UtdWill Arsenal finish in the top four?Yes0%No0%Share your resultsShare your resultsTweet your results Advertisement
Ajax comfortably won the game despite the own goal (Picture: Sky Sports)Tagliafico fired the ball straight into his own net, but shrugged off the mistake with little fuss.Arsenal already have a host of defensive stars under performing and Emery is tipped to make quite a few changes in the summer.If Arsenal qualify for the Champions League, Emery is aiming to sign at least five players in the coming transfer window.But should Arsenal finish outside the top four of the Premier League again, Emery will have just £40m in transfer funds.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City Advertisement Arsenal transfer target Nicolas Tagliafico scores embarrassing own goal for Ajax Coral BarryThursday 4 Apr 2019 5:07 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link190Shares Nicolas Tagliafico own goal for Ajax (Picture: Sky Sports)Nicolas Tagliafico scored a humiliating own goal for Ajax in an otherwise routine win for the Eredivisie leaders against Emmen on Wednesday night.The 5-2 win over Emmen, who are bottom of the league, sent Ajax a point clear of second-place side PSV Eindhoven – who have played a game less.Arsenal are tracking Tagliafico this season as Unai Emery has drawn up a list of full-backs capable of replacing Nacho Monreal.Nicolas Tagliafico with one of the greatest own goals you’ll see this season 😂🤷♂️ pic.twitter.com/TM7wHgUCow— ESPN UK (@ESPNUK) April 3, 2019 Advertisement Comment ADVERTISEMENTCeltic’s star Kieran Tierney and Leicester City defender Ben Chilwell are also up for consideration, but Emery is said to be a big fan of Tagliafico.Ajax value Tagliafico at around £17million, but Arsenal fans will be wary to see the 26-year-old produce a calamitous own goal against Emmen.AdvertisementAdvertisementUnder no real pressure, Tagliafico plays the ball back to his goalkeeper, only for the speed of the pass to catch his stopper off guard.
The International Transport Workers’ Federation (ITF) has called on the Sri Lankan government to release a Ukrainian seafarer who has been detained in Sri Lanka since 2016.Captain Gennadiy Gavrylov has been prevented from leaving Sri Lanka since his arrest on June 23, 2016, in connection with the police investigation relating to the Sri Lanka-flagged offshore support vessel Avant Garde.The Avant Garde was engaged in maritime security and piracy prevention and firearms and ammunition stores were kept on board for the purpose of this role, according to the ITF.In October 2015, the vessel was awaiting clearance to enter port anchored outside Sri Lankan waters on the orders of the company, when it was seized by the country’s authorities and forced to enter its waters. Captain Gavrylov was arrested in relation to illegal importation of arms.“For over three years, Gennadiy Gavrylov has been stranded in Sri Lanka desperate to go home, while Sri Lankan authorities refuse to grant him permission to leave the country,” Stephen Cotton, ITF general secretary, said.“International law is clear on the rights of individuals who are subject to detention by state authorities, if any person is arrested or detained on a criminal charge, they should be permitted to stand trial or be released within a reasonable time,” Cotton added.“Taking into account the circumstances surrounding Captain Gavrylov’s arrest, and taking into consideration his current ill health and the long time he has already spent in detention without charge, we implore the Sri Lankan government to intervene and allow Captain Gavrylov to go home,” concluded Cotton.